Synthesis and complete stereochemical assignment of psymberin/irciniastatin A

…, J García-Fortanet, JK De Brabander

文献索引：Jiang, Xin; Garcia-Fortanet, Jorge; De Brabander, Jef K. Journal of the American Chemical Society, 2005 , vol. 127, # 32 p. 11254 - 11255

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被引用次数: 86

摘要

We describe a concise and flexible synthetic avenue for the preparation of compounds with structures relevant to those proposed for the novel marine-derived differential cytotoxins psymberin and irciniastatin A. Our efforts led to their complete stereochemical assignment and the notion that psymberin and irciniastatin A are identical compounds. Our total synthesis features an interesting termini-differentiating lactolization of a dialdehyde ...