High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor

…, SK Vadivel, P Fan, A Makriyannis

文献索引：Yao, Fen-Mei; Palmer, Sonya L.; Khanolkar, Atmaram D.; Tian, Xiaoyu; Guo, Jianxin; Makriyannis, Alexandros Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 2 p. 115 - 129

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被引用次数: 33

摘要

We have designed and synthesized the first two high affinity covalent anandamide probes for the CB1 receptor by introducing either an electrophilic isothiocyanato or a photoactivatable azido group at the terminal carbon of the arachidonic acid moiety. The