Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents

…, D Asgari, N Baindur, NK Chadha, T Georgiadis…

文献索引：Patch, Raymond J.; Brandt, Benjamin M.; Asgari, Davoud; Baindur, Nand; Chadha, Naresh K.; Georgiadis, Taxiarchis; Cheung, Wing S.; Petrounia, Ioanna P.; Donatelli, Robert R.; Chaikin, Margery A.; Player, Mark R. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6070 - 6074

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被引用次数: 24

摘要

A series of 2′-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as well as the introduction of hydrophilic substituents on the benzene core. Compound 47 inhibits the isolated enzyme (IC50= 0.027 μM) and blocks CSF-1-induced proliferation of bone marrow-derived ...