Selective and potent monoamine oxidase type B inhibitors: substituted semicarbazones and acylhydrazones of aromatic aldehydes and ketones

S Bernard, C Paillat, T Oddos, M Seman…

文献索引：Bernard, S.; Paillat, C.; Oddos, T.; Seman, M.; Milcent, R. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 6 p. 471 - 482

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被引用次数: 15

摘要

The synthesis and the evaluation of the monoamine oxidase A and B inhibitory activities of 21 new substituted acylhydrazones of various aromatic aldehydes and 4-(benzyloxy) acetophenone, and four substituted semicarbazones of benzaldehyde and 4-(benzyloxy) benzaldehyde, are described. The 4-(benzyloxy) phenyl group contributing to a high lipophilicity led to the most active compounds. One of these, compound 3g (IC50= 3 nM, ...