Highly enantioselective synthesis of γ-nitro heteroaromatic ketones in a doubly stereocontrolled manner catalyzed by bifunctional thiourea catalysts based on …
X Jiang, Y Zhang, ASC Chan, R Wang
文献索引：Jiang, Xianxing; Zhang, Yifu; Chan, Albert S. C.; Wang, Rui Organic Letters, 2009 , vol. 11, # 1 p. 153 - 156
A new class of dehydroabietic amine-substituted primary amine-thiourea bifunctional catalysts were designed and synthesized. The doubly stereocontrolled organocatalytic conjugate addition of a variety of heterocycles-bearing ketones to nitroalkenes was investigated for the first time, affording (S)-or (R)-γ-nitro heteroaromatic ketones with excellent enantioselectivities (up to ee> 99%). Furthermore, the nearly optically pure γ- ...
