Synthesis of 2-amino-3-hydroxy-4-substituted pyridines via regioselective metalation of 3-(1-ethylpropyl)-[1, 3] oxazolo [4, 5-b] pyridin-2 (3H)-one and application to …
RA Hartz, KK Nanda, CL Ingalls
文献索引：Hartz, Richard A.; Nanda, Kausik K.; Ingalls, Charles L. Tetrahedron Letters, 2005 , vol. 46, # 10 p. 1683 - 1686
An efficient route to the preparation of 2-amino-3-hydroxy-4-substituted pyridines is described. The key step involves the regioselective metalation and subsequent alkylation of the [1, 3] oxazolo [4, 5-b] pyridin-2 (3H)-one ring system. Base hydrolysis provides access to a variety of 4-substituted pyridines. This chemistry is proved to be useful for the synthesis of corticotropin releasing factor1 receptor ligands.
