Tetrahedron

A convenient new synthesis of quaternary ammonium glucuronides of drug molecules

L Iddon, RA Bragg, JR Harding, AV Stachulski

文献索引：Iddon, Lisa; Bragg, Ryan A.; Harding, John R.; Stachulski, Andrew V. Tetrahedron, 2010 , vol. 66, # 2 p. 537 - 541

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被引用次数: 6

摘要

N-Glucuronides, of various structural types, are frequently encountered as drug metabolites. Efficient chemical synthesis of these compounds, both as analytical standards and for toxicological investigation, is therefore an important goal. Earlier syntheses of N+- glucuronides of aliphatic tertiary amine drugs involved direct reaction of the drug molecule with a bromosugar, but yields were generally low and of poor reproducibility, with many by ...