α, α??Difluoro??H??phosphinates: Useful Intermediates for a Variety of Phosphate Isosteres

A Gautier, G Garipova, C Salcedo…

文献索引：Gautier, Arnaud; Garipova, Goulnara; Salcedo, Carmen; Balieu, Sebastien; Piettre, Serge R. Angewandte Chemie - International Edition, 2004 , vol. 43, # 44 p. 5963 - 5967

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被引用次数: 33

摘要

Research efforts have long since established H-phosphinates 1 as important and valuable intermediates for the preparation of bioactive analogues of natural phosphates (Scheme 1).[1] Despite various methodologies for their easy preparation, the synthesis of phosphonate 2, phosphonothioates 3, and phosphinates 4 remains an area of intense activity.[2] Moreover, major progress has been made in the chemistry of α, α- ...