Reactive ketimino radical acceptors: Intermolecular alkyl radical addition to imines with a phenolic hydroxyl group

H Miyabe, Y Yamaoka, Y Takemoto

文献索引：Miyabe, Hideto; Yamaoka, Yousuke; Takemoto, Yoshiji Journal of Organic Chemistry, 2006 , vol. 71, # 5 p. 2099 - 2106

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被引用次数: 38

摘要

Intermolecular carbon radical addition to the carbon-nitrogen double bond of ketimines was studied. In the study on the reactivity of various aldimines, we found that the aldimine 7 having a phenolic hydroxyl group shows an excellent reactivity toward nucleophilic carbon radicals. A remarkable effect of phenolic hydroxyl group is assumed to be the stabilization of intermediate aminyl radical provided by a hydroxyl group. The screening of reactive ...