Design and synthesis of novel metalloproteinase inhibitors

…, S Yamamoto, Y Nishita, S Itadani, H Habashita…

文献索引：Nakatani, Shingo; Ikura, Masahiro; Yamamoto, Shingo; Nishita, Yoshitaka; Itadani, Satoshi; Habashita, Hiromu; Sugiura, Tsuneyuki; Ogawa, Koji; Ohno, Hiroyuki; Takahashi, Kanji; Nakai, Hisao; Toda, Masaaki Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 15 p. 5402 - 5422

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被引用次数: 19

摘要

A series of N-benzoyl 4-aminobutyric acid hydroxamate analogs were synthesized and evaluated as matrix metalloproteinase inhibitors. Synthetic work was focused on the chemical modification of the 4-aminobutyric acid part using easily available starting materials. As such, chemical modification was carried out using commercially available starting materials such as 4-aminobutyric acid,(+)-and (−)-malic acid, and d-and l-glutamic ...