Dopaminergic and serotonergic activities of imidazoquinolinones and related compounds

…, RF Heier, CG Chidester, WE Hoffmann…

文献索引：Moon, Malcolm W.; Morris, Jeanette K.; Heier, Richard F.; Chidester, Connie G.; Hoffmann, William E.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1076 - 1092

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被引用次数: 40

摘要

The synthesis of 5-(dipropylamino)-5, 6-dihydro-4H-imidazo [4l5, l-ij] quinolin-2 (lH)-one (5), a potent dopamine D2 agonist showing high dopamine/serotonin (5HT1~) selectivity, is described. Dopaminergic activity is associated with the (R)-enantiomer of 5; the (SI- enantiomer shows no dopaminergic activity. A series of analogues where the imidezolone ring wan modified to various 5 or 6membered heterocyclic ringe were prepared. Some of ...