Helvetica chimica acta

First Use of Benzyl Phosphites in the Michaelis??Arbuzov Reaction synthesis of mono??, Di??, and triphosphate analogs

M Saady, L Lebeau, C Mioskowski

文献索引：Saady, Mourad; Lebeau, Luc; Mioskowski, Charles Helvetica Chimica Acta, 1995 , vol. 78, p. 670 - 678

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被引用次数: 39

摘要

Abstract Benzyl phosphites were used in the Micaelis-Arbuzov reaction. Special experimental conditions allowed preparation of a set of phosphonate analogs of mono-, di-, and triphosphate. Furthermore, regioselective monodeprotection makes these molecules useful building blocks for the synthesis of analogs of polyphosphorylated compounds of biological interest (eg nucleotides), after removal of all phosphonate benzyl ester groups ...