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Synthesis, structures, and acute toxicity of gossypol nonsymmetrical aldehyde derivatives

…, NL Vypova, AM Yuldashev, BT Ibragimov…

文献索引:Tilyabaev; Kamaev; Vypova; Yuldashev; Ibragimov; Talipov Russian Journal of Bioorganic Chemistry, 2010 , vol. 36, # 3 p. 390 - 395

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被引用次数: 1

摘要

Abstract Nonsymmetrical aldehyde derivatives of gossypol, a yellow polyphenolic pigment of cottonseed, were synthesized by reactions with ammonia, aniline, 4-aminoantipyrine, and barbituric acid. Their structures were determined by UV spectrophotometry and IR and 1 H NMR spectroscopy methods. Their acute toxicities in white mice were compared with those of gossypol and the corresponding symmetrical analogues. It was demonstrated that in ...