Substituted 2-phenyl-benzimidazole derivatives: novel compounds that suppress key markers of allergy

…, A Sinha, H Banie, RJ Thomas, M Major, M Tanji…

文献索引：Richards, Mark L.; Lio, Shirley Cruz; Sinha, Anjana; Banie, Homayon; Thomas, Richard J.; Major, Michael; Tanji, Mark; Sircar, Jagadish C. European Journal of Medicinal Chemistry, 2006 , vol. 41, # 8 p. 950 - 969

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被引用次数: 35

摘要

The pharmacotherapy of allergy and asthma has traditionally focused on the effecter molecules of the allergic cascade, while neglecting targets that play an early role in their development. Reasoning that IgE is central to the expansion of atopic diseases, we identified and extended a novel family of 2-(substituted phenyl)-benzimidazole inhibitors of IgE response. Pharmacological activity depends on an intact phenylbenzimidazole-bis- ...