Synthesis and antiviral activities of new acyclic and “double-headed” nucleoside analogues

…, X Fan, J Balzarini, J Neyts, E De Clercq, M Prichard…

文献索引：Zhang, Xinying; Amer, Adel; Fan, Xuesen; Balzarini, Jan; Neyts, Johan; De Clercq, Erik; Prichard, Mark; Kern, Earl; Torrence, Paul F. Bioorganic Chemistry, 2007 , vol. 35, # 3 p. 221 - 232

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被引用次数: 7

摘要

To develop an understanding of the structure–activity relationships for the inhibition of orthopoxviruses by nucleoside analogues, a variety of novel chemical entities were synthesized. These included a series of pyrimidine 5-hypermodified acyclic nucleoside analogues based upon recently discovered new leads, and some previously unknown “double-headed” or “abbreviated” nucleosides. None of the synthetic products possessed ...