Synthesis of (R)-bambuterol based on asymmetric reduction of 1-[3, 5-bis (dimethylcarbamoyloxy) phenyl]-2-chloroethanone with incubated whole cells of Williopsis …

K Asami, T Machida, S Jung, K Hanaya, M Shoji…

文献索引：Asami, Kento; Machida, Takuya; Jung, Sonna; Hanaya, Kengo; Shoji, Mitsuru; Sugai, Takeshi Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 97, p. 106 - 109

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被引用次数: 2

摘要

Abstract To achieve the synthesis of (R)-bambuterol, a prodrug of (R)-terbutaline, asymmetric reduction of 1-[3, 5-bis (dimethylcarbamoyloxy) phenyl]-2-chloroethanone with whole cells of Williopsis californica JCM 3600 pre-incubated on glycerol as a carbon source was examined. Initially, the insolubility of this crystalline substrate (mp 126–127 C) in the incubation broth was an obstacle that needed to be overcome. To solve the problem, the ...