Tetrahedron

Novel synthetic approaches to CHBrFI, CHClFI and CHBrClI

DB Li, SC Ng, I Novak

文献索引：Li, Dong Bo; Ng, Siu-Choon; Novak, Igor Tetrahedron, 2002 , vol. 58, # 29 p. 5923 - 5926

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被引用次数: 12

摘要

Three new facile methods for the preparations of racemic mixtures of CHBrFI, CHClFI and CHBrClI are described. Mercuric fluoride was found to be an effective fluorinating agent in fluorinations of CHI2Br (6) and CHI2Cl (8) to yield CHBrFI, CHClFI, respectively. Chlorination of CHI2Br (6) by using antimony pentachloride as a chlorinating agent, afforded CHBrClI in convenient and mild condition.