Ruphos-mediated Suzuki cross-coupling of secondary alkyl trifluoroborates

…, GM Visser, M Visser, TJ Korstanje, JTBH Jastrzebski

文献索引：van den Hoogenband, Adri; Lange, Jos H.M.; Terpstra, Jan Willem; Koch, Melle; Visser, Gerben M.; Visser, Martin; Korstanje, Ties J.; Jastrzebski, Johann T.B.H. Tetrahedron Letters, 2008 , vol. 49, # 26 p. 4122 - 4124

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被引用次数: 51

摘要

A Ruphos-mediated Suzuki cross-coupling between (hetero) aryl bromides and secondary alkyltrifluoroborates is described using palladium catalysis. The Ruphos ligand showed superior properties as compared to S-Phos in this type of reaction. This method constitutes a valuable extension to current methods for the straightforward production of secondary- alkylated (hetero) aryl derivatives.