Efficient Synthesis of 2??Methyl Derivatives of 1, 1′??Bi (2??naphthol) and 1, 1′??Bi (2??phenols)

M Solinas, RE Meadows, C Wilson…

文献索引：Solinas, Maurizio; Meadows, Rebecca E.; Wilson, Claire; Blake, Alexander J.; Woodward, Simon European Journal of Organic Chemistry, 2007 , # 10 p. 1613 - 1623

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被引用次数: 4

摘要

Abstract Reaction of 1, 1′-binaphthol and structurally related 1, 1′-biphenols with sulfonylating reagents [RSO 2 Cl; R= 4-Tol, Ph] leads to clean, ultraselective monoderivatisation, shown crystallographically in one case (2-OH–2′-OTs–1, 1′- binaphthyl). Reaction of the remaining 2-hydroxy function with either Tf 2 O or NfF [Nf= nonaflate, CF 3 (CF 2) 3 SO 2-] affords the protected/activated cores (2-R 1 O–2′-R 2 O– ...