Novel potent apoA-I peptide mimetics that stimulate cholesterol efflux and pre-β particle formation in vitro

…, C Burton, A Langella, X Chen, K Zytko, A Pessi…

文献索引：Ingenito, Raffaele; Burton, Charlotte; Langella, Annunziata; Chen, Xun; Zytko, Karolina; Pessi, Antonello; Wang, Jun; Bianchi, Elisabetta Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 236 - 239

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被引用次数: 4

摘要

Reverse cholesterol transport (RCT) is believed to be the primary mechanism by which HDL and its major protein apoA-I protect against atherosclerosis. Starting from the inactive 22- amino acid peptide representing the consensus sequence of the class A amphipathic helical repeats of apoA-I, we designed novel peptides able to mobilize cholesterol from macrophages in vitro, and to stimulate the formation of 'nascent HDL'particles, with ...