One of the reactions of α-ketophosphonates which has as yet remained unexplored is their C-alkylation at the adjacent position to the C O. Indeed, there are very few examples in the literature pertaining to derivatization at the β-carbon of α-ketophosphonates. Two examples of halogenation of α-ketophosphonates are reported using either elemental bromine or chlorine [11], or sulfuryl chloride ( Scheme 1) [12]. No base is required for either reaction and it is not certain if the ...
