Alkyl halides are very useful intermediates in organic synthesis. They react with nucleophiles such as amines or alkoxides to give the corresponding amines or ethers and can be lithiated to introduce electrophiles via a halogen–lithium exchange reaction. The most common precursors for preparation of alkyl halides are alcohols, and their conversion into halides is one of the most frequently used functional group transformation reactions. [ 1 1. Di Deo , M. ; Marcantoni , ...