Optimized strategies to synthesize β-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers

R Le Provost, T Wille, L Louise, N Masurier…

文献索引：Le Provost, Romain; Wille, Timo; Louise, Ludivine; Masurier, Nicolas; Mueller, Susanne; Reiter, Georg; Renard, Pierre-Yves; Lafont, Olivier; Worek, Franz; Estour, Franois Organic and Biomolecular Chemistry, 2011 , vol. 9, # 8 p. 3026 - 3032

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被引用次数: 16

摘要

A new generation of organophosphate (OP) scavengers was obtained by synthesis of β- cyclodextrin-oxime derivatives 8–12. Selective monosubstitution of β-cyclodextrin was the main difficulty in order to access these compounds, because reaction onto the oligosaccharide was closely related to the nature of the incoming group. For this purpose, non-conventional activation conditions were also evaluated. Intermediates 5 and 7 were ...