Synthesis of novel octa-cationic and non-ionic 1, 2-ethanediamine substituted zinc (Ⅱ) phthalocyanines and their in vitro anti-cancer activity comparison
A Wang, L Zhou, K Fang, L Zhou, Y Lin, J Zhou…
文献索引：Wang, Ao; Zhou, Li; Fang, Kelong; Zhou, Lin; Lin, Yun; Zhou, Jiahong; Wei, Shaohua European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 12 - 21
Novel tetra-substituted zinc phthalocyanines (Pcs) bearing 1, 2-ethanediamine group and the quaternized derivatives were synthesized and characterized. The photophysical and cellular properties of these Pcs were investigated. The results indicated that the quaternized ionic effect can greatly improve the water-solubility of Pcs and reduce their aggregation degree in aqueous solution. Comparative studies with quaternized phthalocyanine and its ...
