Benzanilides with spasmolytic activity: chemistry, pharmacology, and SAR

G Brunhofer, N Handler, K Leisser, CR Studenik…

文献索引：Brunhofer, Gerda; Handler, Norbert; Leisser, Klaus; Studenik, Christian R.; Erker, Thomas Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 11 p. 5974 - 5981

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被引用次数: 11

摘要

The following study describes the synthesis of new benzanilide derivatives and their pharmacological investigation on smooth muscle preparations of guinea pigs. All compounds were synthesized in good yields and showed a spasmolytic activity without significant effect on vascular smooth muscles and heart muscle preparations. Moreover, further pharmacological investigations as well as in silico studies were performed to ...