Il Farmaco

In vitro–in vivo antifungal evaluation and structure–activity relationships of 3H-1, 2-dithiole-3-thione derivatives

…, ML Aimar, M Sortino, R Gomez, A Sturniollo, A Juarez…

文献索引：Giannini, Fernando A.; Aimar, Mario L.; Sortino, Maximiliano; Gomez, Roxana; Sturniollo, Alejandro; Juarez, Americo; Zacchino, Susana; De Rossi, Rita H.; Enriz, Ricardo D. Farmaco, 2004 , vol. 59, # 4 p. 245 - 254

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被引用次数: 12

摘要

As part of our project devoted to the search of new antifungal agents, we report here the in vitro–in vivo antifungal evaluations and a structure–activity relationship (SAR) study of 17 thione derivatives. Some compounds of this series exhibited remarkable antifungal activity against a broad spectrum of pathogenic opportunistic fungi. SAR studies provide a useful information for the determination of the minimum structural requirements for producing the ...