Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the α3β4* nicotinic acetylcholine receptors through modifications …
SC Bergmeier, KA Ismail, KM Arason, S McKay…
文献索引：Bergmeier, Stephen C.; Ismail, Khadiga A.; Arason, Kristjan M.; McKay, Susan; Bryant, Darrell L.; McKay, Dennis B. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3739 - 3742
The development of novel agents for the differentiation of neuronal nicotinic acetylcholine receptors (nAChRs) is important for the treatment of a variety of pathological conditions. We have prepared and evaluated a number of simpler analogues of the norditerpeniod alkaloid methyllycaconitine (MLA) in an effort to understand molecular determinants of nAChR• small molecule interactions. We have previously reported the synthesis and evaluation of a ...
