Metabolism of pentacarboxylate porphyrinogens by highly purified human coproporphyrinogen oxidase: Further evidence for the existence of an abnormal pathway for …

CL Cooper, CM Stob, MA Jones, TD Lash

文献索引：Cooper, Christopher L.; Stob, Christian M.; Jones, Marjorie A.; Lash, Timothy D. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 22 p. 6244 - 6251

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被引用次数: 10

摘要

An abnormal series of porphyrin tetracarboxylic acids known as the isocoproporphyrins, are commonly excreted by patients suffering from the disease porphyria cutanea tarda (PCT). These porphyrins appear to arise by bacterial degradation of dehydroisocoproporphyrinogen that is generated by the premature metabolism of the normal pentacarboxylate intermediate (5dab) by coproporphyrinogen oxidase (copro'gen ...