Bioorganic chemistry

Design, synthesis, molecular docking studies and in vitro screening of ethyl 4-(3-benzoylthioureido) benzoates as urease inhibitors

A Saeed, MS Khan, H Rafique, M Shahid, J Iqbal

文献索引：Saeed, Aamer; Khan, Muhammad Siraj; Rafique, Hummera; Shahid, Mohammad; Iqbal, Jamshed Bioorganic Chemistry, 2014 , vol. 52, p. 1 - 7

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被引用次数: 11

摘要

Abstract Thioureas are exceptionally versatile building blocks towards the synthesis of wide variety of heterocyclic systems, which also possess extensive range of pharmacological activities. The substituted benzoic acids were converted into corresponding acid chlorides, these acid chlorides were then treated with potassium thiocyanate in acetone and then the reaction mixture was refluxed for 1–2 h afford ethyl 4-(3-benzoylthioureido) benzoates ...