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Synthesis of N-alkoxycarbonyl-3-substituted tetramic acids and functionalized enols via C-acylation reactions of active methylene compounds with N- …

…, M Micha-Screttas, O Igglessi-Markopoulou

文献索引:Detsi, Anastasia; Micha-Screttas, Maria; Igglessi-Markopoulou, Olga Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 15 p. 2443 - 2449

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被引用次数: 26

摘要

The-hydroxysuccinimide esters of-alkoxycarbonyl-α-amino acids react with active methylene compounds (malonic and acyl acetic esters), under basic conditions, to produce- alkoxycarbonyl-3-substituted tetramic acids 7–17; in the case of the-hydroxysuccinimide ester of-alanine, the corresponding optically active t