Novel iodine-124 labeled EGFR inhibitors as potential PET agents for molecular imaging in cancer

M Shaul, G Abourbeh, O Jacobson, Y Rozen…

文献索引：Shaul, Mazal; Abourbeh, Galith; Jacobson, Orit; Rozen, Yulia; Laky, Desideriu; Levitzki, Alexander; Mishani, Eyal Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 13 p. 3421 - 3429

全文：HTML全文

被引用次数: 67

摘要

The in vivo results with our previously reported irreversible labeled inhibitor [11C]-ML03 suggested that more chemically stable inhibitors, labeled with a longer-lived radioisotope, could be better candidates for molecular imaging of epidermal growth factor receptor (EGFR) positive tumors. On the basis of this hypothesis we synthesized three new irreversible tyrosine kinase (TK) inhibitors with various chemical reactivities. The three ...