Journal of medicinal chemistry

Heterosubstituted anthracene-9, 10-dione analogs. The synthesis and antitumor evaluation of 5, 8-bis [(aminoalkyl) amino] naphtho [2, 3-b] thiophene-4, 9-diones

AP Krapcho, ME Petry, MP Hacker

文献索引：Krapcho, Paul A.; Petry, Mary E.; Hacker, Miles P. Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2651 - 2655

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被引用次数: 34

摘要

A number of 5, 8-bis [(aminoalkyl) amino] naphtho [2, 3-b] thiophene-4, g-diones have been synthesized and evaluated for antitumor activity against L1210 leukemia both in vitro and in vivo. Two of the congeners exhibited in vivo activities quite comparable to that of mitoxantrone.