A novel photoaffinity probe for the LTD 4 receptor

M Gallant, N Sawyer, KM Metters…

文献索引：Gallant, Michel; Sawyer, Nicole; Metters, Kathleen M.; Zamboni, Robert J. Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 1 p. 63 - 72

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被引用次数: 8

摘要

A novel photoaffinity probe for the leuktriene D4 receptor (LTD4) is described. L-745310, which is structurally related to the potent LTD4 antagonist MK-0476 (Singulair™), was found to selectively label a 43-kDa protein in guinea-pig lung membrane previously identified as the LTD4 receptor.