Canadian Journal of Chemistry

Phenyl phosphorodichloridate in the synthesis of cyclic phosphate diesters of biological interest

CL Penney, B Belleau

文献索引：Penney,C.L.; Belleau,B. Canadian Journal of Chemistry, 1978 , vol. 56, p. 2396 - 2404

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被引用次数: 17

摘要

The general usefulness of phenyl phosphorodichloridate (PPDC) in the synthesis of non- nucleoside cyclic phosphates is described. The method is illustrated with several examples including cyclic phosphates incorporating six to nine members. However, the reagent could not be used for the preparation of five-membered cyclic phosphates or 3', 5'-cycloadenylic acid (cAMP) from adenosine. Based on a number of observations, the conclusion was ...