Synthesis and structure–activity relationships of phenoxypyridine derivatives as novel inhibitors of the sodium–calcium exchanger

T Kuramochi, A Kakefuda, H Yamada, I Sato…

文献索引：Kuramochi, Takahiro; Kakefuda, Akio; Yamada, Hiroyoshi; Sato, Ippei; Taguchi, Taku; Sakamoto, Shuichi Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 19 p. 5039 - 5056

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被引用次数: 9

摘要

The sodium–calcium exchanger (NCX) is known as the transporter that controls the concentration of Ca2+ in cardiac myocytes. In the setting of heart failure and myocardial ischemia-reperfusion, NCX underlies an arrhythmogenic transient inward current responsible for delayed after––depolarizations and nonreentrant initiation of ventricular tachycardia. NCX is an attractive target for treatment in heart failure and myocardial ...