The Journal of Organic Chemistry

Synthetic studies in unnatural cyclic amino acids

VJ Lee, RB Woodward

文献索引：Lee,V.J.; Woodward,R.B. Journal of Organic Chemistry, 1979 , vol. 44, # 14 p. 2487 - 2491

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被引用次数: 18

摘要

Vast methodology exists in the literature for the synthesis of cr-amino acids and their derivatives. However, there is a paucity of information pertaining to the chemistry of unnat. ura1 cyclic amino acids, specifically those with a nitrogen--oxygen bond to the carboxylate function. We were interested in an unambiguous synthesis of~~-tetrahydro-2H-1, 2-oxazine- 3-carboxylic acids (la, R