Synthesis of 5-alkenylated D4T analogues via the Pd-catalyzed cross-coupling reaction

A Ciurea, C Fossey, S Benzaria, D Gavriliu…

文献索引：Ciurea; Fossey; Benzaria; Gavriliu; Delbederi; Lelong; Laduree; Aubertin; Kirn Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 9 p. 1655 - 1670

全文：HTML全文

被引用次数: 12

摘要

The target compounds 5-[N-(6-amino-hexyl)-acrylamide]-2′, 3′-didehydro-2′, 3′- dideoxy-uridine (12) and 5-{N-[5-(methoxycarbonyl)-pentyl]-acrylamide}-2′, 3′-didehydro- 2′, 3′-dideoxy-uridine (15) were prepared by the palladium acetate-triphenylphosphine- catalyzed reaction of the 5′-O-acetyl-5-iodo-d4T analogue (3). These compounds 12 and 15 can be used to prepare nucleotide probes carrying fluorescent labels and were ...