SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT 7 receptor ligands among phenylpiperazine hydantoin derivatives

…, K Kucwaj, B Filipek, K Kieć-Kononowicz

文献索引：Handzlik, Jadwiga; Bojarski, Andrzej J.; Satala, Grzegorz; Kubacka, Monika; Sadek, Bassem; Ashoor, Abrar; Siwek, Agata; Wiecek, Malgorzata; Kucwaj, Katarzyna; Filipek, Barbara; Kiec-Kononowicz, Katarzyna European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 324 - 339

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被引用次数: 11

摘要

Abstract The current study is focused on newly developed phenylpiperazine derivatives of aromatic methylhydantoin differing in mutual positions of methyl and phenyl moieties. The new compounds were synthesized using Bucherer–Bergs reaction, two-phase alkylation, ...