Organic letters

Allyl Sulfones as Precursors to Allylzincs in the Palladium-Catalyzed Zinc-ene Cyclization: Highly Efficient Synthesis of Enantiopure (-)-Erythrodiene

K Deng, J Chalker, A Yang, T Cohen

文献索引：Deng, Kai; Chalker, Justin; Yang, Ao; Cohen, Theodore Organic Letters, 2005 , vol. 7, # 17 p. 3637 - 3640

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被引用次数: 24

摘要

Easily prepared allyl phenyl sulfones, capable of introduction of the alkene by electrophilic α- substitution, are superior to allyl acetates as substrates for Pd-catalyzed Zn-ene cyclizations, providing C5 or C4N rings with cis-1, 2-vinyl and-CH2Zn substituents. Several examples, with different methods of substrate preparation, are presented.