Design, synthesis, and biological activities of closantel analogues: Structural promiscuity and its impact on Onchocerca volvulus

…, M Samje, F Cho-Ngwa, S Lustigman…

文献索引：Garner, Amanda L.; Gloeckner, Christian; Tricoche, Nancy; Zakhari, Joseph S.; Samje, Moses; Cho-Ngwa, Fidelis; Lustigman, Sara; Janda, Kim D. Journal of Medicinal Chemistry, 2011 , vol. 54, # 11 p. 3963 - 3972

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被引用次数: 13

摘要

Onchocerciasis, or river blindness, is a neglected tropical disease that affects more than 37 million people worldwide, primarily in Africa and Central and South America. We have disclosed evidence that the larval-stage-specific chitinase, OvCHT1, may be a potential biological target for affecting nematode development. On the basis of screening efforts, closantel, a known anthelmintic drug, was discovered as a potent and highly specific ...