New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase

M Fonvielle, H Therisod, M Hemery…

文献索引：Fonvielle, Matthieu; Therisod, Helene; Hemery, Marion; Therisod, Michel Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 410 - 413

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被引用次数: 7

摘要

We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. The best tested compound, phosphono-propionohydroxamic acid, with a Ki of 6μM, might be of interest as an anti- obesity drug.