Chemistry Letters

Direct Conversion of Azides and Benzyl Carbamates to t-Butyl Carbamates Using Polymethylhydrosiloxane and Pd-C.

S Chandrasekhar, L Chandraiah, CR Reddy…

文献索引：Chandrasekhar; Chandraiah; Raji Reddy; Venkat Reddy Chemistry Letters, 2000 , # 7 p. 780 - 781

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被引用次数: 15

摘要

N-(t-Butoxycarbonyl) functionality plays a major role as the protective group for amines in the synthesis of unusual amino acids and also in peptide chemistry.1 This is due to its reasonable stability and easy removal under mild conditions. In the former case an amino group is generally introduced through azide and then reduced to amine followed by blocking prefer- ably as t-butyl carbamate. A few attempts have been made recently to achieve this transformation in ...