A convergent strategy towards taxol. A facile enantioselective entry into a fully functionalized ring A system

…, CK Hwang, EJ Soresen, CF Clairborne

文献索引：Nicolaou, K. C.; Hwang, C.-K.; Sorensen, E. J.; Clairborne, C. F. Journal of the Chemical Society, Chemical Communications, 1992 , # 16 p. 1117 - 1118

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被引用次数: 21

摘要

Key intermediates 10-12 related to the taxol ring A system have been synthesized in enantiomerically pure form by a short and efficient route featuring a Diels-Alder reaction and a Corey oxazaborolidine reduction. ... Taxol 1, the novel polyoxygenated diterpenoid originally isolated from the western yew Taxus brevefulia,l has recently moved to centre stage as one of the most promising anticancer agents to emerge in recent times.2 In this communication we disclose a convergent ...