Tetrahedron letters

Effect of InCl 3 on the addition of Grignard reagents to α, β-unsaturated carbonyl compounds

BG Kelly, DG Gilheany

文献索引：Kelly, Brian G.; Gilheany, Declan G. Tetrahedron Letters, 2002 , vol. 43, # 5 p. 887 - 890

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被引用次数: 19

摘要

Control of 1, 2-versus 1, 4-addition of organometallic reagents to enones remains a long- standing problem. There is still no satisfactory 1, 2-directing agent comparable to the 1, 4- directing effect of copper salts. We report that the presence of just 5 mol% indium (III) chloride can significantly alter the amount of 1, 2-product formed in these reactions.