Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for β-amyloid plaque imaging

EK Ryu, YS Choe, KH Lee, Y Choi…

文献索引：Ryu, Eun Kyoung; Choe, Yearn Seong; Lee, Kyung-Han; Choi, Yong; Kim, Byung-Tae Journal of Medicinal Chemistry, 2006 , vol. 49, # 20 p. 6111 - 6119

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被引用次数: 140

摘要

Alzheimer's disease (AD) is pathologically characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain, and thus, the in vivo imaging of plaques and tangles would be beneficial for the early diagnosis of AD. It has been suggested that 5- hydroxy-1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 4, 6-heptatrien-3-one (curcumin) may be responsible for low age-adjusted prevalence of AD in India. In the present study, eight ...