Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents

…, CC O'Hare, JA Hartley, D Ross, J Butler

文献索引：Hargreaves, Robert H. J.; O'Hare, C. Caroline; Hartley, John A.; Ross, David; Butler, John Journal of Medicinal Chemistry, 1999 , vol. 42, # 12 p. 2245 - 2250

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被引用次数: 16

摘要

The cytotoxicities and DNA cross-linking abilities of several alkyl-substituted diaziridinylquinones have been investigated. The cytotoxicities were determined in DT- diaphorase-rich (H460 and HT29) and-deficient (H596 and BE) cell lines. It was shown that the cytotoxicities in these cell lines correlated with the relative rates of reduction by the purified human enzyme and with the cross-linking efficiencies. The rates of reduction by ...