Synthesis and gastrointestinal pharmacology of a 3E, 5Z diene analog of misoprostol
PW Collins, SW Kramer, AF Gasiecki…
文献索引：Collins, Paul W.; Kramer, Steven W.; Gasiecki, Alan F.; Weier, Richard M.; Jones, Peter H.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 193 - 197
A stereospecific synthesis and the gastric antisecretory and diarrheal activity of a 3E, 5Z diene analogue of misoprostol are described. The key intermediate in the synthesis was an CY chain truncated acetylene that was obtained by a cuprate/enolate capture procedure on the corresponding cyclopentenone. Palladium-catalyzed coupling of the acetylene with methyl 4-iodo-3 (E)-butenoate provided the conjugated enyne. Although selective ...
