Toxicity and osmoprotective activities of analogues of glycine betaine obtained by solid phase organic synthesis towards Sinorhizobium meliloti

A Cosquer, V Pichereau, D Le Mée, M Le Roch…

文献索引：Cosquer, Anne; Pichereau, Vianney; Mee, Didier Le; Roch, Myriam Le; Renault, Jacques; Carboni, Bertrand; Uriac, Philippe; Bernard, Theophile Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 1 p. 49 - 54

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被引用次数: 6

摘要

Seven analogues of the bacterial osmoprotectant glycine betaine (GB, trimethylammonioacetate), in which the methyl groups of the Me3N+ moiety are replaced by various substituents, were obtained by SPOS using Wang resin. Their biological activities (osmoprotection vs toxicity), appeared closely related to their uptake efficiency and their catabolism in the betaine-demethylating model bacterium Sinorhizobium meliloti.