Reaction of 5??aminopyrazole derivatives with ethoxymethylene??malononitrile and its analogues

K Nagahara, H Kawano, S Sasaoka…

文献索引：Nagahara; Kawano; Sasaoka; Ukawa; Hirama; Takada; Cottam; Robins Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 1 p. 239 - 243

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被引用次数: 25

摘要

Abstract A one-pot synthesis using 5-aminopyrazole derivatives 1 with ethoxymethylenemalononitrile (EMMN), ethyl ethoxymethylenecyanoacetate (EMCA) or diethyl ethoxymethylenemalonate (DEMM) gave pyrazolo-[1, 5-a] pyrimidine compounds 2, 4, 8. Also, the one step reaction of EMCA with hydrazine hydrate afforded ethyl (4- ethoxycarbonyl-5-pyrazolyl) aminomethylenecyanoacetate 3c. On the other hand, the ...