Tetrahedron letters

Synthesis and optical resolution of dl-cis-2-fluorocycloproplylamine, the key component of the new generation of quinolonecarboxylic acid, DU-6859

…, M Hashimoto, Y Kobayashi, T Katoh, K Nakatani…

文献索引：Tamura; Hashimoto; Kobayashi; Katoh; Nakatani; Kamada; Hayakawa; Akiba; Terashima Tetrahedron Letters, 1992 , vol. 33, # 24 p. 3483 - 3486

全文：HTML全文

被引用次数: 32

摘要

Abstract The title synthesis was accomplished by featuring highly cis-selective cyclpropanation of an N-vinylcarbamate with zinc-monofluorocarbenoid followed by deprotection of the formed N-(cis-2-fluorocyclopropyl) carbamate. Optical resolution of dl-cis- 2-fluorocyclopropylamine was also achieved by employing l-menthyl chloroformate as a resolving agent.